Transform the way you do abdominoplasty

TissuGlu® is a lysine-based synthetic adhesive that is made in the United States. TissuGlu delivers 10X the strength of fibrin sealants to effectively hold tissue planes together, providing a clinically-proven alternative to traditional drains.

graph showing TissuGlu strength versus sealants


  • Lysine-based urethane adhesive that creates a strong bond between tissue layers to reduce dead space
  • More than 10X stronger than fibrin sealant, with holding power comparable to cyanoacrylate
  • Each drop provides 10 pounds of shear force resistance
tissuglu gun with part labels


  • Single-part applicator that requires no mixing or special storage
  • Ergonomically designed, single-use applicator delivers TissuGlu drops in a precise grid pattern, creating multiple points of contact in minutes
  • Takes only 30 to 45 minutes to fully cure, giving time to close the wound
tissuglu gun with part labels
tissuglu application


  • Synthetic composition means no concern about human-or-animal-derived products
  • Benign degradants composed primarily of lysine derivatives, CO2, and ethanol are readily metabolized by the body
  • Demonstrated safety through a prospective, randomized, pivotal study and an FDA panel review

Complete directions for use

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Directions for using TissuGlu

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Reference: 1. Data on file, Cohera Medical, Inc.

Important TissuGlu® Surgical Adhesive Safety Information


TissuGlu® Surgical Adhesive is indicated for the approximation of tissue layers where subcutaneous dead space exists between the tissue planes in abdominoplasty.


Do not use in patients with known or suspected allergies to urethane-based or isocyanate-containing products.


  • Do not use TissuGlu® Surgical Adhesive in patients who have had prior exposure to TissuGlu®. Immunological response associated with repeat TissuGlu® exposure has not been studied.
  • The effectiveness for the treatment of patients with BMI > 28 has not been established. Higher BMI patients have a propensity for fluid accumulation and may have an increased risk of seroma formation.
  • Effectiveness was not observed in weight loss patients undergoing abdominoplasty. Weight loss patients have a propensity for fluid accumulation and may have an increased risk of seroma formation and aspiration.

TissuGlu® may reduce the need for drains after surgery. By using TissuGlu® instead of drains, you may:

  • Return to normal activities more quickly
  • Experience less discomfort and pain than when drains are used
  • Have fewer invasive treatments for fluid management. The results showed that 73% of TissuGlu® patients had no treatments after surgery. However, some patients did require additional invasive treatments including reinsertion of drains.

Clinical studies were performed using TissuGlu®. There were no increased safety risks with the use of TissuGlu® than when drains were used. Potential complications associated with the use of the device and the tummy tuck procedures include seroma (fluid) formation. These complications may require treatments such as drain placement and/or fluid removal by needle, which may be performed in the operating room. Additional potential complications include wound healing issues, rash/redness, surgical site or incision infection, scarring, hematoma (bruise or swelling), incision separation, and immunological reaction.

Safety Information:
For full safety information please visit, contact your doctor, or call Cohera Customer Support at 1-800-641-7458.

TissuGlu® Surgical Adhesive is currently approved for sale in the United States for the approximation of tissue layers where subcutaneous dead space exists between the tissue planes in abdominoplasty. TissuGlu® Surgical Adhesive received European CE Mark in 2011, where it is approved for large flap surgical procedures such as abdominoplasty. TissuGlu® Surgical Adhesive is not approved for sale in any other region. Any questions related to the indication for use should be directed to your Cohera Medical Account Manager or to Cohera Medical Corporate Clinical Affairs. Refer to the complete TissuGlu® Surgical Adhesive Directions for Use for prescribing and usage information.