TissuGlu®: A clinically proven alternative to drains

In a prospective, randomized, multicenter clinical trial (N=130), TissuGlu was proven to be an effective alternative to drains for fluid management in abdominoplasty. The study evaluated the number of invasive treatments needed for fluid management issues in patients with and without drains over the course of 3 months. A patient questionnaire assessing quality of life measures was also administered.1

TissuGlu was FDA approved in the United States for abdominoplasty in 2015.

TissuGlu simplifies patients' recovery

smoother road with tissuglu

Patients who had TissuGlu experienced a better quality of life during recovery

Patients who were able to shower (%)

towel chart graphic

Patients in the TissuGlu group returned to a normal work schedule approximately 3.5 days sooner than those with drains2

TissuGlu: Demonstrated safety in clinical studies1

  • The rates of postoperative wound-related complications were comparable between the TissuGlu and control (drains) groups
  • No unanticipated device-related adverse events were observed
  • Safety outcomes with TissuGlu were similar to literature reports of other abdominoplasty studies
  • To date, TissuGlu has been used safely and effectively in thousands of postmarket cases, with no serious device-related safety issues reported
93% of patients receiving TissuGlu were drain-free93% of patients receiving TissuGlu were drain-free

of TissuGlu patients recovered drain-free1

While some people may still require additional fluid management, a clinical study showed that 3 out of 4 patients who had TissuGlu required no further fluid-related treatment1,2

3 out of 4 girls shaded in

Experience TissuGlu
for yourself

Request a sales representative demonstration and get started with TissuGlu

Request TissuGlu >

Give your practice the TissuGlu advantage

Learn More

References: 1. Hunstad JP, Michaels J, Burns AJ, et al. A prospective, randomized, multicenter trial assessing a novel lysine-derived urethane adhesive in a large flap surgical procedure without drains. Aesthetic Plast Surg. 2015;39(4):616-624. 2. Data on file, Cohera Medical, Inc.

Important TissuGlu® Surgical Adhesive Safety Information


TissuGlu® Surgical Adhesive is indicated for the approximation of tissue layers where subcutaneous dead space exists between the tissue planes in abdominoplasty.


Do not use in patients with known or suspected allergies to urethane-based or isocyanate-containing products.


  • Do not use TissuGlu® Surgical Adhesive in patients who have had prior exposure to TissuGlu®. Immunological response associated with repeat TissuGlu® exposure has not been studied.
  • The effectiveness for the treatment of patients with BMI > 28 has not been established. Higher BMI patients have a propensity for fluid accumulation and may have an increased risk of seroma formation.
  • Effectiveness was not observed in weight loss patients undergoing abdominoplasty. Weight loss patients have a propensity for fluid accumulation and may have an increased risk of seroma formation and aspiration.

TissuGlu® may reduce the need for drains after surgery. By using TissuGlu® instead of drains, you may:

  • Return to normal activities more quickly
  • Experience less discomfort and pain than when drains are used
  • Have fewer invasive treatments for fluid management. The results showed that 73% of TissuGlu® patients had no treatments after surgery. However, some patients did require additional invasive treatments including reinsertion of drains.

Clinical studies were performed using TissuGlu®. There were no increased safety risks with the use of TissuGlu® than when drains were used. Potential complications associated with the use of the device and the tummy tuck procedures include seroma (fluid) formation. These complications may require treatments such as drain placement and/or fluid removal by needle, which may be performed in the operating room. Additional potential complications include wound healing issues, rash/redness, surgical site or incision infection, scarring, hematoma (bruise or swelling), incision separation, and immunological reaction.

Safety Information:
For full safety information please visit http://tissuglu.com/safety, contact your doctor, or call Cohera Customer Support at 1-800-641-7458.

TissuGlu® Surgical Adhesive is currently approved for sale in the United States for the approximation of tissue layers where subcutaneous dead space exists between the tissue planes in abdominoplasty. TissuGlu® Surgical Adhesive received European CE Mark in 2011, where it is approved for large flap surgical procedures such as abdominoplasty. TissuGlu® Surgical Adhesive is not approved for sale in any other region. Any questions related to the indication for use should be directed to your Cohera Medical Account Manager or to Cohera Medical Corporate Clinical Affairs. Refer to the complete TissuGlu® Surgical Adhesive Directions for Use for prescribing and usage information.